Liposomal formulations of poorly soluble camptothecin: drug retention and biodistribution

Pharmaceutical Formulation for Poorly Water Soluble Camptothecin Analogues

Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers

Liposomes are frequently used as pharmaceutical nanocarriers to deliver poorly water-soluble drugs such as temoporfin, cyclosporine A, amphotericin B, and paclitaxel to their target site. Optimal drug delivery depends on understanding the release kinetics of the drug molecules from the host liposomes during the journey to the target site and at the target site. Transfer of drugs in model system...

Solubility Enhancement of Poorly Water Soluble Celecoxib for Parenteral Formulations

Celecoxib, a diaryl substituted pyrazole, is practically insoluble in water which precludes its use in parenteral and liquid dosage forms. This study explores the solubility enhancement of celecoxib using hydrotropy and cosolvency solubilization approaches. The equilibrium solubility studies were performed using hydrotropes piperazine, sodium citrate, and urea and cosolvents PEG 200, PEG 400, P...

Nanoemulsion Formulations for Improved Oral Delivery of Poorly Soluble Drugs

The objective of this study was to develop nanoemulsion formulations for enhancement of oral bioavailability of paclitaxel, a model hydrophobic drug and P-glycoprotein substrate. The oil-in-water (o/w) nanoemulsions were made with pine nut oil as the internal oil phase, egg lecithin as the primary emulsifier, and water as the external phase. Stearylamine and deoxycholic acid were used to impart...

Transcriptome-wide elucidation of liposomal formulations for anticancer drug delivery

Although widely used in chemotherapy, free doxorubicin (Dox) might enhance cell malignancy undesirably. Liposomal Dox (Doxlipo) has been clinically approved for the treatment of breast cancer due to reduced systematical toxicity and increased tumor targeting, yet the transcriptome-wide elucidation of the Doxlipo formulations remains elusive. To this end, we explored the impact of two Dox liposo...